CHEMISTRY (CHGN)
CHGN111. INTRODUCTORY CHEMISTRY. 3.0 Semester Hrs.
(S) Introductory college chemistry. Elementary atomic structure and the periodic chart, chemical bonding, chemical reactions and stoichiometry of chemical reactions, chemical equilibrium, thermochemistry, and properties of gases. Must not be used for elective credit. Does not apply toward undergraduate degree or g.p.a. 3 hours lecture and 3 hours lab; 3 semester hours.
CHGN121. PRINCIPLES OF CHEMISTRY I. 4.0 Semester Hrs.
Study of matter and energy based on atomic structure, correlation of properties of elements with position in periodic chart, chemical bonding, geometry of molecules, phase changes, stoichiometry, solution chemistry, gas laws, and thermochemistry. 3 hours lecture, 3 hours lab; 4 semester hours. Approved for Colorado Guaranteed General Education transfer. Equivalency for GT-SC1.
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- Design and conduct experiments to predict and explain simple chemical and physical processes.
- Calculate or measure quantities using the correct precision and units.
- Explain the general quantum mechanical model for an atom and perform simple spectroscopy calculations.
- Predict the products and calculate amounts of substances in a chemical reaction.
- Describe the trends in periodic properties of elements and explain why they occur.
- Identify the primary types of bonds in a substance, and types of intermolecular forces, if present.
- Explain molecular-level differences between solids, liquids, gases for pure ionic and covalent substances.
- Calculate amount of energy flow during a chemical reaction or phase change, classifying it as heat or work.
- Determine 3D shape and polarity of small molecules and polyatomic ions to predict trends in properties.
- Explain in basic terms how each concept above applies to modern science or engineering issues.
CHGN122. PRINCIPLES OF CHEMISTRY II (SC1). 4.0 Semester Hrs.
Continuation of CHGN121 concentrating on chemical kinetics, gas laws, thermodynamics, electrochemistry and chemical equilibrium (acid- base, solubility, complexation, and redox). Laboratory experiments emphasizing quantitative chemical measurements. 3 hours lecture; 3 hours lab, 4 semester hours. Prerequisite: Grade of C- or better in CHGN121.
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- Predict physical properties of pure substances & solutions resulting from chemical bonding & intermolecular forces.
- Compare/contrast the direction & spontaneity of chemical & physical processes based on energy & entropy changes.
- Construct chemical rate laws from sequences of molecular collisions; Analyze the factors that determine reaction rates.
- Predict the extend & direction of chemical reactions approaching equilibrium; Assess the impact of stresses to a system at equilibrium.
- Determine the properties & composition of aqueous systems by applying equilibrium concepts & acid/base theory.
- Design experiments & clearly communicate your findings to scientists & non-scientists.
- Explain how each concept above applies to modern science & engineering challenges.
CHGN125. MOLECULAR ENGINEERING & MATERIALS CHEMISTRY. 4.0 Semester Hrs.
Studies of the interactions of matter and energy in chemical reactions and physical processes. Building on principles from CHGN121, the course systematically explores the relationships between processes, structures and properties, starting from the atomic and molecular level. It provides a framework to apply knowledge of chemical bonding and material properties to engineering design, with an emphasis on the Engineering Grand Challenges and the discovery of new process-structure-property relationships. There is a strong focus on the underlying principles of kinetics and equilibrium, and their general applicability, strongly rooted in the first and second law of thermodynamics. Examples of these principles come primarily from solid-state systems. Laboratory experiments emphasize conceptual understanding of structure-property relationships through both hands-on and computational analysis, reinforced by quantitative chemical measurements. Prerequisite: Grade of C- or better in CHGN121. 3 hours lecture; 3 hours lab; 4 semester hours.
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- Knowledge: A student will be able to:
- Comprehension: A student will be able to:
- Application: A student will be able to:
- Analysis: A student will be able to:
CHGN198. SPECIAL TOPICS. 0-6 Semester Hr.
(I, II) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once. Prerequisite: none. Variable credit; 1 to 6 credit hours. Repeatable for credit under different titles.
CHGN199. INDEPENDENT STUDY. 1-6 Semester Hr.
(I, II) Individual research or special problem projects supervised by a faculty member, also, when a student and instructor agree on a subject matter, content, and credit hours. Prerequisite: "Independent Study" form must be completed and submitted to the Registrar. Variable credit; 1 to 6 credit hours. Repeatable for credit.
CHGN209. INTRODUCTION TO CHEMICAL THERMODYNAMICS. 3.0 Semester Hrs.
Introduction to the fundamental principles of classical thermodynamics, with particular emphasis on chemical and phase equilibria. Volume-temperature-pressure relationships for solids, liquids, and gases; ideal and non-ideal gases. Introduction to kineticmolecular theory of ideal gases and the Maxwell-Boltzmann distributions. Work, heat, and application of the First Law to closed systems, including chemical reactions. Entropy and the Second and Third Laws; Gibbs Free Energy. Chemical equilibrium and the equilibrium constant; introduction to activities & fugacities. One- and two-component phase diagrams; Gibbs Phase Rule. May not also receive credit for CBEN210 or GEGN330. Prerequisites: CHGN121, CHGN122 or CHGN125, MATH111, MATH112, PHGN100. 3 hours lecture; 3 semester hours.
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- Analyze and identify thermodynamic concepts involving spontaneous vs. non-spontaneous processes.
- Describe heat and work on the atomic/molecular level.
- Predict the heat capacities of gases using molecular degrees of freedom and the Equipartition Principle.
- Explain the temperature-dependence of heat capacities, including the effect of phase changes.
- Differentiate and relate heat vs. temperature.
- Quantitatively utilize the First Law and explain internal energy and enthalpy changes.
- Distinguish between real and ideal gases and explain the role of the intermolecular potential.
- Interpret and explain (both qualitatively and using calculations) the thermodynamics of phase changes and chemical reactions.
- Interpret various phase diagrams (and their important projections) for both pure substances and binary mixtures.
- Interpret the Second and Third Laws of Thermodynamics at the atomic level.
- Predict and explain spontaneity using entropy and free energy calculations.
- Analyze and interpret heat engines and heat pumps involving ideal gases, especially regarding the Second Law.
CHGN221. ORGANIC CHEMISTRY I. 3.0 Semester Hrs.
Structure, properties, and reactions of the important classes of organic compounds, introduction to reaction mechanisms. Prerequisites: Grade of C- or better in CHGN122 or CHGN125. 3 hours lecture; 3 semester hours.
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- Gain an in-depth understanding of chemical bonding.
- Be able to name, draw, and determine the structures of organic molecules.
- Understand the properties of organic molecules.
- Understand chemical reactions and reactivity.
CHGN222. ORGANIC CHEMISTRY II. 3.0 Semester Hrs.
Continuation of CHGN221. 3 hours lecture; 3 semester hours. Prerequisite: Grade of C- or better in CHGN221.
CHGN223. ORGANIC CHEMISTRY I LABORATORY. 1.0 Semester Hr.
Laboratory exercises including purification techniques, synthesis, and characterization. Experiments are designed to support concepts presented in the CHGN221. Students are introduced to Green Chemistry principles and methods of synthesis and the use of computational software. 3 hours laboratory, 1 semester hour. Prerequisite: CHGN221 or concurrent enrollment.
CHGN224. ORGANIC CHEMISTRY II LABORATORY. 1.0 Semester Hr.
Laboratory exercises using more advanced synthesis techniques. Experiments are designed to support concepts presented in CHGN222.
CHGN298. SPECIAL TOPICS. 1-6 Semester Hr.
(I, II) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once. Prerequisite: none. Variable credit; 1 to 6 credit hours. Repeatable for credit under different titles.
CHGN299. INDEPENDENT STUDY. 1-6 Semester Hr.
(I, II) Individual research or special problem projects supervised by a faculty member, also, when a student and instructor agree on a subject matter, content, and credit hours. Prerequisite: "Independent Study" form must be completed and submitted to the Registrar. Variable credit; 1 to 6 credit hours. Repeatable for credit.
CHGN311. INTRODUCTION TO NANOSCIENCE AND NANOTECHNOLOGY. 3.0 Semester Hrs.
The primary objective of this course is to provide all students a suitable background to understand the role nanotechnology will play in future technologies and the underpinning principals involved. 3 hours lecture; 3 semester hours. Prerequisite: CHGN121.
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- Understanding of the phenomena and properties arising from nanoscale materials as a function of changing size and shape.
- Understanding of the terminology and techniques associated with assembling, manipulating and measuring properties at the nanoscale.
- Understanding the different classes of nanoscale materials, their properties and applications.
- Ability to read and assess the landmark nanotechnology papers in the literature.
- Utilizing the above developed knowledge to identify and interpret literature in state of the art applications interfacing nanotechnology with your field of interest.
CHGN323. QUALITATIVE ORGANIC ANALYSIS AND APPLIED SPECTROSCOPY. 2.0 Semester Hrs.
Identification, separation and purification of organic compounds including use of modern physical and instrumental methods. 1 hour lecture; 3 hours lab; 2 semester hours. Prerequisite: Grade of C- or better in CHGN222, CHGN224.
CHGN335. INSTRUMENTAL ANALYSIS. 3.0 Semester Hrs.
Principles of AAS, AES, Visible-UV, IR, NMR, XRF, XRD, XPS, electron, and mass spectroscopy; gas and liquid chromatography; data interpretation. Prerequisite: CHGN122 with a grade of C- or better or CHGN125 with a grade of C- or better.
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- Understand what is happening at an atomic/molecular level for each grouping of techniques. What characteristic is being measured?
- Understand when a technique is (not) applicable.
- Compare subtechniques within a family.
- List/sketch components of an instrument and explain the importance of each.
- Understand how to optimize instruments.
- Differentiate good and poor results.
- Use the techniques for qualitative and/or quantitative analyses.
- Determine performance characteristics such as accuracy, precision, selectivity, sensitivity, limit of detection, and calibration methods.
CHGN336. ANALYTICAL CHEMISTRY. 3.0 Semester Hrs.
Theory and techniques of gravimetry, titrimetry (acid-base, complexometric, redox, precipitation), electrochemical analysis, chemical separations; statistical evaluation of data. Prerequisite: CHGN221, CHGN122 with a grade of C- or better or CHGN125 with a grade of C- or better.
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- Choose appropriate analytical samples, perform correct measurements, understand sources of errors.
- Perform basic statistical data analyses and understand the principles behind them.
- Write mathematical expressions for different kinds of chemical equilibria (including acid-base, precipitation, complexation, and redox equilibria) and use them to calculate species concentrations in solution and to design and understand chemical analyses.
- Apply basic principles of electrochemistry to design and understand chemical analyses involving potentiometry and electroanalytical techniques.
- (With CHGN 337 Analytical Chemistry Laboratory) apply quantitative laboratory skills and techniques.
CHGN337. ANALYTICAL CHEMISTRY LABORATORY. 1.0 Semester Hr.
Laboratory exercises emphasizing sample preparation and instrumental methods of analysis. Prerequisite: CHGN221 (C- or better), CHGN 223. Co-requisite: CHGN336.
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- Reinforce, through laboratory exercises, the principles of analytical chemistry that are presented in CHGN 336 Analytical Chemistry and CHGN 335 Instrumental Analysis.
- Train students in the principles and practice of sample preparation and quantitative chemical measurements.
- Provide students with the opportunity to work with modern analytical instrumentation.
- By the end of the course, students should be able to select the most appropriate techniques for specific analyses and know how to determine the practical limitations of each method.
CHGN340. COOPERATIVE EDUCATION. 3.0 Semester Hrs.
(I, II, S) Supervised, full-time, chemistry-related employment for a continuous six-month period (or its equivalent) in which specific educational objectives are achieved. Prerequisite: Second semester sophomore status and a cumulative grade-point average
of at least 2.00. 0 to 3 semester hours. Cooperative Education credit does not count toward graduation except under special conditions.
CHGN341. INORGANIC CHEMISTRY I. 3.0 Semester Hrs.
The chemistry of the elements and periodic trends in reactivity is discussed. Particular concepts covered include group theory, symmetry, bonding in ionic and metallic crystal, acid-base theories, coordination chemistry, ligand field theory and radioactivity. 3 hours lecture; 3 semester hours. Prerequisite: CHGN222 and CHGN209 or CBEN210.
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- Students should be able to assess, evaluate or apply periodic trends, group theory, coordination chemistry, molecular orbital theory and crystal field theory.
CHGN351. PHYSICAL CHEMISTRY: A MOLECULAR PERSPECTIVE I. 4.0 Semester Hrs.
A study of chemical systems from a molecular physical chemistry perspective. Includes an introduction to quantum mechanics, atoms and molecules, spectroscopy, bonding and symmetry, and an introduction to modern computational chemistry. Prerequisites: MATH225, PHGN200, CHGN209 with a grade of C- or better or CBEN210.
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- Demonstrate basic knowledge of quantum mechanics and its application.
- Demonstrate basic knowledge of spectroscopic methods that are used to detect molecules and to investigate their properties.
- Demonstrate knowledge and intuition of molecular-scale processes that allow rationalization of how molecular-scale parameters can affect macroscopic properties.
- Use the methods of chemical kinetics to determine and analyze the rates of chemical reactions.
- Interpret and discuss reaction equilibria in terms of free energies and chemical potentials.
- Explain the origin and need of activity; apply these concepts to ideal and real solutions of electrolytes and non-electrolytes.
CHGN353. PHYSICAL CHEMISTRY: A MOLECULAR PERSPECTIVE II. 0-4 Semester Hr.
A continuation of CHGN351. Includes statistical thermodynamics, chemical kinetics, chemical reaction mechanisms, electrochemistry, and selected additional topics. 3 hours lecture; 3 hours laboratory; 4 semester hours. Prerequisite: CHGN351.
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- Develop an understanding of the molecular basis of properties.
- Synthesize material you’ve seen in earlier physical chemistry courses into a coherent perspective on chemical systems.
CHGN395. INTRODUCTION TO UNDERGRADUATE RESEARCH. 1.0 Semester Hr.
(I) (WI) Introduction to Undergraduate Research is designed to introduce students to the research endeavor. Topics include ethics, hypothesis testing, critical evaluation of the scientific literature, scientific writing, bibliographic software, and proposal preparation. Prerequisites: Completion of the chemistry curriculum through the Spring semester of the sophomore year. Credit: 1 semester hour.
CHGN396. UNDERGRADUATE RESEARCH. 1-5 Semester Hr.
(I,II,S) Individual research project for freshman, sophomores or juniors under direction of a member of the departmental faculty. Prerequisites: None. Variable credit; 1 to 5 credit hours. Repeatable for credit. Seniors should take CHGN495 instead of CHGN396.
CHGN398. SPECIAL TOPICS IN CHEMISTRY. 1-6 Semester Hr.
(I, II) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once. Prerequisite: none. Variable credit; 1 to 6 credit hours. Repeatable for credit under different titles.
CHGN399. INDEPENDENT STUDY. 1-6 Semester Hr.
(I, II) Individual research or special problem projects supervised by a faculty member, also, when a student and instructor agree on a subject matter, content, and credit hours. Prerequisite: "Independent Study" form must be completed and submitted to the Registrar. Variable credit; 1 to 6 credit hours. Repeatable for credit.
CHGN401. INORGANIC CHEMISTRY II. 3.0 Semester Hrs.
The chemistry of the elements and several applications are related to inorganic chemistry are considered in this course. Particular concepts covered include experimental techniques, chemistry specific to groups of elements, catalysis and industrial processes, inorganic materials and nanotechnology, and other applications of inorganic chemistry. Prerequisite: CHGN341. 3 hours lecture; 3 semester hours.
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- Students should be able to apply fundamental considerations of inorganic chemistry to "real world" scenarios.
CHGN403. INTRODUCTION TO ENVIRONMENTAL CHEMISTRY. 3.0 Semester Hrs.
Equivalent with CHGC505,
Processes by which natural and anthropogenic chemicals interact, react and are transformed and redistributed in various environmental compartments. Air, soil and aqueous (fresh and saline surface and groundwaters) environments are covered, along with specialized environments such as waste treatment facilities and the upper atmosphere. Prerequisites: CHGN209 or CBEN210. 3 hours lecture; 3 semester hours.
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- NA
CHGN406. INTRODUCTION TO GEOCHEMISTRY. 3.0 Semester Hrs.
A comprehensive introduction to the basic concepts and principles of geochemistry, coupled with a thorough overview of related principles of thermodynamics and kinetics. Topics covered include: chemical bonding, key chemical reactions, mineral chemistry, soils and nanogeoscience, differentiation of the earth, controls on natural waters, stable and radiogenic isotopes and organic and biogeochemistry. Equivalent with CHGC503. Prerequisite: CHGN122 or CHGN125, GEGN101.
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- None
CHGN409. BIOLOGICAL INORGANIC CHEMISTRY. 3.0 Semester Hrs.
This course starts with a short introduction to inorganic chemistry and biology. The course then focuses on core bioinorganic chemistry topics, including metalloprotein structure and function; characterization of bioinorganic systems; metal assimilation, metabolism, and homeostasis; and metals in medicine. We also briefly cover special topics, such as metallo-endocrinology, extremophiles, biomineralization, and supramolecular bioinorganic chemistry. We investigate recent advances in the field of bioinorganic chemistry, introduce many leading scientists in the field, and explore scientific literature. Students are assessed through two open-resource, take-home exams (midterm and final) covering course material. Students also explore a topic of their choice through a class presentation and a writing assignment. Students will benefit from having taken at least one of the following courses: organic chemistry, inorganic chemistry, or biochemistry.
CHGN410. SURFACE CHEMISTRY. 3.0 Semester Hrs.
Equivalent with MLGN510,
Introduction to colloid systems, capillarity, surface tension and contact angle, adsorption from solution, micelles and micro - emulsions, the solid/gas interface, surface analytical techniques, van der Waal forces, electrical properties and colloid stability, some specific colloid systems (clays, foams and emulsions). Students enrolled for graduate credit in MLGN510 must complete a special project. Prerequisite: CHGN209 or CBEN210.
CHGN411. APPLIED RADIOCHEMISTRY. 3.0 Semester Hrs.
This course is designed for those who have a budding interest radiochemistry and its applications. A brief overview of radioactivity and general chemistry will be provided in the first three weeks of the course. Follow-on weeks will feature segments focusing on the radiochemistry in the nuclear fuel cycle, radioisotope production, nuclear forensics and the environment. Prerequisite: CHGN122 or CHGN125.
CHGN413. CHEMISTRY OF THE LANTHANIDES AND ACTINIDES. 3.0 Semester Hrs.
This course is designed to introduce students to the chemistry and properties lanthanide and actinide elements, collectively known as the f-block. These elements are key components of nearly all electronic devices, and you are currently using about eight of them if you are reading this on a cellphone or computer. They also possess fascinating and complex chemistry that can be quite different from transition metals. The course will start with a history of their discovery and the developments that took place during the Manhattan Project. The course will then continue with fundamentals of f-block chemistry with a focus on electronic structure and thermodynamics. Following this, other core topics will include: 1) environmental chemistry including efforts to remediate Cold War legacy nuclear sites and how chemistry plays a role in this. 2) Aqueous Chemistry. 3) Coordination chemistry. 4) Optical and magnetic properties and the selection rules that determine these phenomena. 5) Catalysis, including small molecule activation and polymerization. 5) Separations and recycling. 6) Nuclear Medicine. Each year the course will be partially tailored to recent discoveries and adjusted in focus based on class interests.
View Course Learning Outcomes
- Students will have an understanding of why f-block elements are fundamentally different from elements in other parts of the periodic table.
- Students will understand why the unique electronic properties of f-block elements play key roles in numerous technologies
- Students will understand the pros and cons of nuclear energy including the recycling and storage of nuclear waste
CHGN420. PHYSICAL ORGANIC CHEMISTRY. 3.0 Semester Hrs.
This course will introduce students to the fundamental chemical and physical principles that underly mechanistic organic chemistry with a basis in frontier orbital theory, combining valence bond and molecular orbital theories. Topics covered will include thermochemistry, conformational analysis, bond dissociation energies and acidity, kinetics, linear free energy relationships, bonding and molecular orbital theory, and non-covalent interactions. A broad goal of this course is to teach students the underlying principles behind the content introduced in Organic Chemistry I and II. What do we mean when we say that a molecule or conformation is more or less stable than another? What factors control the rate and selectivity of a chemical reaction? What experiments can be used to probe an organic reaction mechanism? These are all questions that we will aim to address by the end of this course. Prerequisites: CHGN222, CHGN351.
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- Correlate composition and structure of molecules with their reactivity.
- Compare and contrast the spatial and energetic relationships of frontier orbitals.
- Relate organic molecule frontier orbitals with the molecule's structure and reactivity.
- Evaluate the thermodynamics of organic molecule reactivity based on molecular structure.
- Correlate reaction mechanisms with kinetics using transition state theory.
- Design experiments for measuring and correlating thermodynamics and kinetics.
CHGN422. POLYMER CHEMISTRY LABORATORY. 1.0 Semester Hr.
Prerequisites: CHGN221, CHGN223. 3 hours lab; 1 semester hour.
CHGN423. SOLID-STATE CHEMISTRY. 3.0 Semester Hrs.
Dependence of properties of solids on chemical bonding and structure; principles of crystal growth, crystal imperfections, reactions and diffusion in solids, and the theory of conductors and semiconductors Prerequisite: CHGN 121.
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- 1. Develop foundational understanding of the atomic structure of crystalline solid-state materials, including symmetry, crystal systems, Bravais lattices, space groups, and Miller indices. Connect these concepts to diffraction and scattering
- 2. Connect bonding and electronic structure to functional properties, i.e. electronic transport, light absorption and emission, phonons/lattice dynamics, etc.
- 3. Develop the ability to critically read, synthesize, and discuss the literature corpus surrounding concepts in solid-state materials chemistry.
CHGN428. BIOCHEMISTRY. 3.0 Semester Hrs.
Introductory study of the major molecules of biochemistry: amino acids, proteins, enzymes, nucleic acids, lipids, and saccharides- their structure, chemistry, biological function, and biosynthesis. Stresses bioenergetics and the cell as a biological unit of organization. Discussion of classical genetics, molecular genetics, and protein synthesis. Co-requisite: CHGN222.
CHGN429. BIOCHEMISTRY II. 3.0 Semester Hrs.
A continuation of CHGN428. Topics include: nucleotide synthesis; DNA repair, replication and recombination; transcription, translation and regulation; proteomics; lipid and amino acid synthesis; protein target and degradation; membranes; receptors and signal transduction. Prerequisite: CHGN428.
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- The learning objectives involve a detailed study of the synthetic reactions for biochemical building blocks and biopolymers. This starts with the integration of CO2 and N2 into synthetic pathways. The construction of the primary 20 amino acids, nucleic acids, fatty acids and carbohydrates will be studied in detail. The light capture and CO2 fixation pathways in photosynthetic organisms will be covered extensively. The breakdown of fatty acids, nucleic acids and amino acids to central metabolites will be covered. The incorporation of building blocks into biopolymers (proteins, DNA/RNA, oligosaccharides) will be incorporated. DNA repair mechanisms and gene regulation will also be studied. General chemical themes regarding equilibria, redox processes, protein structure/function, reaction kinetics and thermodynamics will be extensively reinforced. Biopolymer formation through DNA/RNA polymerase and ribosome functions will be detailed.
CHGN430. INTRODUCTION TO POLYMER SCIENCE. 3.0 Semester Hrs.
Equivalent with MLGN530,
An introduction to the chemistry and physics of macromolecules. Topics include the properties and statistics of polymer solutions, measurements of molecular weights, molecular weight distributions, properties of bulk polymers, mechanisms of polymer formation, and properties of thermosets and thermoplastics including elastomers. Pre requisite: CHGN222. 3 hour lecture, 3 semester hours.
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- Draw chemical structures, name, and determine synthetic procedures for representative polymers.
- Describe the methods for the polymerization of different polymers and the benefits and drawbacks of different methods.
- Describe the kinetics associated with different polymerization methods as well as the statistics governing the syntheses.
- Describe molecular weight characterization techniques.
- Describe the solution properties of polymeric materials with an understanding of the Flory-Huggins theory (furthermore, relate this to the phase behavior of blends).
- Describe the fundamental principles that govern the morphology of polymers.
- Express an understanding of the principles that govern the glass transition temperature.
- Understand and describe the origin of the mechanical and rheological response of polymeric materials.
- Interview successfully for a job in the polymer industry by expressing the knowledge gained from this course.
CHGN431. INTRODUCTORY BIOCHEMISTRY LABORATORY. 2.0 Semester Hrs.
The link between the structure of a material and its properties is ubiquitous across all fields. Throughout the Biochemistry lab course, we will have the opportunity to explore both protein and nucleic acids through various techniques and analyses that probe the structure-property relationship of biomolecules that subsequently allows us to tap into molecular function. The selection of experiments is intentionally designed to provide exposure to a broad range of modern experimental strategies to enrich and solidify material covered within the CHGN428/429 sequence. Co-requisite: CHGN428.
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- Students will gain proficiency in basic biochemistry laboratory techniques.
- Students will generate hypotheses and analyze data.
CHGN435. PHYSICAL BIOCHEMISTRY. 3.0 Semester Hrs.
Apply physical chemical principles to understand property-function relationships of biochemical molecules, and investigate biochemical instrumentation and quantitative analyses common to biochemistry. Methods discussed include light/fluorescence microscopy, biomolecular structure determination, i.e., X-ray crystallography, cryo-electron microscopy and NMR, scattering techniques, biomolecular motors, and more. Prerequisite: CHGN 428 + CHGN 209 or equivalent (CBEN 210 or BIOL 301) Co-requisite: N/A.
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- 1) Demonstrate basic knowledge of thermodynamics and statistical mechanics, and their applications in biochemistry
- 2) Demonstrate basic knowledge of quantum mechanics and its applications in biochemistry
- 3) Demonstrate basic knowledge of common spectroscopic and imaging methods used in biochemistry
- 4) Develop grant-writing skills, particularly in relation to explaining scientific concepts clearly and concisely
- 5) Develop oral presentation skills when disseminating scientific information
CHGN441. THE CHEMISTRY AND BIOCHEMISTRY OF PHARMACEUTICALS. 3.0 Semester Hrs.
This course will examine a broad range of pharmaceuticals, including but not limited to controlled substances, treatments for cardiovascular, respiratory, and infectious diseases, as well as cannabinoids and performance-enhancing substances. The history, pharmacology, and, in some cases, the synthesis of these pharmaceuticals will be covered. Prerequisite: CHGN222, CHGN428.
View Course Learning Outcomes
- Students will be able to describe different general mechanisms of action of pharmaceuticals
- Describe different chemical treatments to specific ailments and diseases along with side effects
- Differentiate site and mechanism of action and how agonists and antogonist drugs interact at drug receptor sites
- Explain nomenclature used to name and classify drugs
CHGN445. CHEMICAL BIOLOGY. 3.0 Semester Hrs.
The analysis of biological systems from the perspective of organic/inorganic and physical chemistry, including chemical reactions for the synthetic preparation of biomolecules and the chemistry behind different biotechnological developments and tools. A strong emphasis on the mechanistic basis of biochemical transformations is included. Strategies for directing pharmaceuticals or diagnostics to different subcellular locales will be presented. A survey of key advancements in the field of chemical biology will be drawn from the primary literature. Prerequisite: CHGN 222, CHGN 428.
View Course Learning Outcomes
- 1. Understand the molecular-level and atomistic origins of how structure imparts reactivity, based on principles from organic and physical organic chemistry.
- 2. Develop a working knowledge of strategies to direct chemical reagents to different subcellular locales.
- 3. Become familiar with the primary literature describing key advances in the field of chemical biology.
- 4. Be able to use the theories, concepts, and tools of chemical biology to predict how compounds may interact with biological systems.
- 5. Propose novel research to address an outstanding question in the field.
CHGN462. MICROBIOLOGY. 3.0 Semester Hrs.
Equivalent with CHGN562,
(II) This course will cover the basic fundamentals of microbiology, such as structure and function of prokaryotic versus eukaryotic cells; viruses; classification of microorganisms; microbial metabolism, energetics, genetics, growth and diversity, microbial interactions with plants, animals, and other microbes. Special focus will be on pathogenic bacteriology, virology, and parasitology including disease symptoms, transmission, and treatment. 3 hours lecture, 3 semester hours. Prerequisite: CBEN120.
CHGN475. COMPUTATIONAL CHEMISTRY. 3.0 Semester Hrs.
This class provides a survey of techniques of computational chemistry, including quantum mechanics (both Hartree-Fock and density functional approaches) and molecular dynamics. Emphasis is given to the integration of these techniques with experimental programs of molecular design and development. Prerequisites: CHGN351, CHGN401. 3 hours lecture; 3 semester hours.
CHGN490. CHEMISTRY FIELD SESSION. 6.0 Semester Hrs.
(WI) Professional-level chemistry experience featuring modules including organic/polymer synthesis and characterization, inorganic nanomaterial investigations, computational chemistry, environmental chemical analysis , biochemistry and technical report writing. 6-week summer session; 6 semester hours. Prerequisite: CHGN323, CHGN341, and CHGN351.
CHGN495. UNDERGRADUATE RESEARCH. 1-5 Semester Hr.
(I, II, S) (WI) Individual research project under direction of a member of the Departmental faculty. Prerequisites: selection of a research topic and advisor, preparation and approval of a research proposal, completion of chemistry curriculum through the junior year. Variable credit; 1 to 5 credit hours. Repeatable for credit.
CHGN497. INTERNSHIP. 1-6 Semester Hr.
(I, II, S) Individual internship experience with an industrial, academic, or governmental host supervised by a Departmental faculty member. Prerequisites: Completion of chemistry curriculum through the junior year. Variable credit; 1 to 6 credit hours.
CHGN498. SPECIAL TOPICS IN CHEMISTRY. 1-6 Semester Hr.
(I, II) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once. Prerequisite: none. Variable credit; 1 to 6 credit hours. Repeatable for credit under different titles.
CHGN499. INDEPENDENT STUDY. 0.5-6 Semester Hr.
(I, II) Individual research or special problem projects supervised by a faculty member, also, when a student and instructor agree on a subject matter, content, and credit hours. Prerequisite: "Independent Study" form must be completed and submitted to the Registrar. Variable credit; 1 to 6 credit hours. Repeatable for credit.
CHGN502. ADVANCED INORGANIC CHEMISTRY. 3.0 Semester Hrs.
Detailed examination of concepts such as molecular symmetry, group theory, molecular orbital theory, ligand field theory, and crystal field theory. Additional topics include spectroscopy, inorganic reaction mechanisms, and organometallic chemistry.
CHGN503. ADV PHYSICAL CHEMISTRY I. 3.0 Semester Hrs.
(II) Quantum chemistry of classical systems. Principles of chemical thermodynamics. Statistical mechanics with statistical calculation of thermodynamic properties. Theories of chemical kinetics. 3 hours lecture; 3 semester hours. Prerequisite: none.
CHGN505. ADVANCED ORGANIC CHEMISTRY. 3.0 Semester Hrs.
Detailed discussion of the more important mechanisms of organic reaction. Structural effects and reactivity. The application of reaction mechanisms to synthesis and structure proof. Prerequisite: none. 3 hours lecture; 3 semester hours.
CHGN507. ADVANCED ANALYTICAL CHEMISTRY. 3.0 Semester Hrs.
(I) Review of fundamentals of analytical chemistry. Literature of analytical chemistry and statistical treatment of data. Manipulation of real substances; sampling, storage, decomposition or dissolution, and analysis. Detailed treatment of chemical equilibrium as related to precipitation, acid-base, complexation and redox titrations. Potentiometry and UV-visible absorption spectrophotometry.
Prerequisite: none. 3 hours lecture; 3 semester hours.
CHGN508. ANALYTICAL SPECTROSCOPY. 3.0 Semester Hrs.
(II) Detailed study of classical and modern spectroscopic methods; emphasis on instrumentation and application to analytical chemistry problems. Topics include: UV-visible spectroscopy, infrared spectroscopy, fluorescence and phosphorescence, Raman spectroscopy, arc and spark emission spectroscopy, flame methods, nephelometry and turbidimetry, reflectance methods, Fourier transform methods in spectroscopy, photoacoustic spectroscopy, rapid-scanning spectroscopy. Prerequisite: none. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN509. BIOLOGICAL INORGANIC CHEMISTRY. 3.0 Semester Hrs.
This course starts with a short introduction to inorganic chemistry and biology. The course then focuses on core bioinorganic chemistry topics, including metalloprotein structure and function; characterization of bioinorganic systems; metal assimilation, metabolism, and homeostasis; and metals in medicine. We also briefly cover special topics, such as metallo-endocrinology, extremophiles, biomineralization, and supramolecular bioinorganic chemistry. We investigate recent advances in the field of bioinorganic chemistry, introduce many leading scientists in the field, and explore scientific literature. Students are assessed through two open-resource, take-home exams (midterm and final) covering course material. Students also explore a topic of their choice through a class presentation and a writing assignment. There are no formal prerequisites for the class; however, students will benefit from having taken at least one of the following courses: organic chemistry, inorganic chemistry, or biochemistry.
CHGN510. CHEMICAL SEPARATIONS. 3.0 Semester Hrs.
(II) Survey of separation methods, thermodynamics of phase equilibria, thermodynamics of liquid-liquid partitioning, various types of chromatography, ion exchange, electrophoresis, zone refining, use of inclusion compounds for separation, application of separation technology for determining physical constants, e.g., stability constants of complexes. Prerequisite: CHGN507. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN511. APPLIED RADIOCHEMISTRY. 3.0 Semester Hrs.
(II) The Applied Radiochemistry course is designed for those who have a budding interest radiochemistry and its applications. A brief overview of radioactivity and general chemistry will be provided in the first three weeks of the course. Follow-on weeks will feature segments focusing on the radiochemistry in the nuclear fuel cycle, radioisotope production, nuclear forensics and the environment. 3 hours lecture and discussion; 3 semester hours. Prerequisite: CHGN 122 or CHGN 125.
CHGN512. COLLOID AND SURFACE CHEMISTRY. 3.0 Semester Hrs.
Introduction to colloid systems, capillarity, surface tension and contact angle, adsorption from solution, micelles and micro - emulsions, the solid/gas interface, surface analytical techniques, van der Waal forces, electrical properties and colloid stability, some specific colloid systems (clays, foams and emulsions) will be introduced.
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- Gain knowledge in fundamental chemical principles and processes occuring at interfaces.
CHGN513. CHEMISTRY OF THE LANTHANIDES AND ACTINIDES. 3.0 Semester Hrs.
This course is designed to introduce students to the chemistry and properties lanthanide and actinide elements, collectively known as the f-block. These elements are key components of nearly all electronic devices, and you are currently using about eight of them if you are reading this on a cellphone or computer. They also possess fascinating and complex chemistry that can be quite different from transition metals. The course will start with a history of their discovery and the developments that took place during the Manhattan Project. The course will then continue with fundamentals of f-block chemistry with a focus on electronic structure and thermodynamics. Following this, other core topics will include: 1) environmental chemistry including efforts to remediate Cold War legacy nuclear sites and how chemistry plays a role in this. 2) Aqueous Chemistry. 3) Coordination chemistry. 4) Optical and magnetic properties and the selection rules that determine these phenomena. 5) Catalysis, including small molecule activation and polymerization. 5) Separations and recycling. 6) Nuclear Medicine. Each year the course will be partially tailored to recent discoveries and adjusted in focus based on class interests.
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- At the completion of this course, students will: Have an understanding of why f-block elements are fundamentally different from elements in other parts of the periodic table.
- Understand why the unique electronic properties of f-block elements play key roles in numerous technologies.
- Understand the pros and cons of nuclear energy including the recycling and storage of nuclear waste.
CHGN515. CHEMICAL BONDING IN MATERIALS. 3.0 Semester Hrs.
(I) Introduction to chemical bonding theories and calculations and their applications to solids of interest to materials science. The relationship between a material’s properties and the bonding of its atoms will be examined for a variety of materials. Includes an introduction to organic polymers. Computer programs will be used for calculating bonding parameters. Prerequisite: none. 3 hours lecture; 3 semester hours.
CHGN520. PHYSICAL ORGANIC CHEMISTRY. 3.0 Semester Hrs.
This course will introduce students to the fundamental chemical and physical principles that underly mechanistic organic chemistry with a basis in frontier orbital theory, combining valence bond and molecular orbital theories. Topics covered will include thermochemistry, conformational analysis, bond dissociation energies and acidity, kinetics, linear free energy relationships, bonding and molecular orbital theory, and non-covalent interactions. A broad goal of this course is to teach students the underlying principles behind the content introduced in Organic Chemistry I and II. What do we mean when we say that a molecule or conformation is more or less stable than another? What factors control the rate and selectivity of a chemical reaction? What experiments can be used to probe an organic reaction mechanism? These are all questions that we will aim to address by the end of this course. Prerequisites: CHGN222, CHGN351, or equivalent.
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- Correlate composition and structure of molecules with their reactivity.
- Compare and contrast the spatial and energetic relationships of frontier orbitals.
- Relate organic molecule frontier orbitals with the molecule's structure and reactivity.
- Evaluate the thermodynamics of organic molecule reactivity based on molecular structure.
- Correlate reaction mechanisms with kinetics using transition state theory.
- Design experiments for measuring and correlating thermodynamics and kinetics.
CHGN523. SOLID STATE CHEMISTRY. 3.0 Semester Hrs.
(I) Dependence of properties of solids on chemical bonding and structure; principles of crystal growth, crystal imperfections, reactions and diffusion in solids, and the theory of conductors and semiconductors. Prerequisite: none. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN529. BIOCHEMISTRY II. 3.0 Semester Hrs.
A continuation of CHGN428. Topics include: nucleotide synthesis; DNA repair, replication and recombination; transcription, translation and regulation; proteomics; lipid and amino acid synthesis; protein target and degradation; membranes; receptors and signal transduction. Prerequisite: CHGN 428.
CHGN535. PHYSICAL BIOCHEMISTRY. 3.0 Semester Hrs.
Apply physical chemical principles to understand property-function relationships of biochemical molecules, and investigate biochemical instrumentation and quantitative analyses common to biochemistry. Methods discussed include light/fluorescence microscopy, biomolecular structure determination, i.e., X-ray crystallography, cryo-electron microscopy and NMR, scattering techniques, biomolecular motors, and more. Prerequisite: CHGN 428 + CHGN 209 or equivalent (CBEN 210 or BIOL 301) Co-requisite: N/A.
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- 1) Demonstrate basic knowledge of thermodynamics and statistical mechanics, and their applications in biochemistry
- 2) Demonstrate basic knowledge of quantum mechanics and its applications in biochemistry
- 3) Demonstrate basic knowledge of common spectroscopic and imaging methods used in biochemistry
- 4) Develop grant-writing skills, particularly in relation to explaining scientific concepts clearly and concisely
- 5) Develop oral presentation skills when disseminating scientific information
CHGN536. ADVANCED POLYMER SYNTHESIS. 3.0 Semester Hrs.
(II) An advanced course in the synthesis of macromolecules. Various methods of polymerization will be discussed with an emphasis on the specifics concerning the syntheses of different classes of organic and inorganic polymers. 3 hours lecture, 3 semester hours Prerequisite: CHGN 430, CBEN 415, MLGN 530.
CHGN538. ORGANIC SEMICONDUCTORS: NEW TECHNOLOGIES FOR EMERGING APPLICATIONS. 3.0 Semester Hrs.
(II) Organic Light Emitting Diodes (OLEDs) is a display technology that can be found in many commercial products such as the smartphones and tablets. This technology was on the R&D bench-top just 10 years ago and has now reached high volume manufacturing. Other related technologies like organic photovoltaics (OPV) and organic thin film transistors (OTFT) are now on the heels of commercialization as well. This course will provide an overview on how this meteoric rise from bench-top to commercial products occurred as well as the design, synthesis and uses of conjugated organic small molecules, oligomers and polymers in applications such as OLEDs (for flat panel displays and lighting), OPV, OTFT, and sensors. Additional topics to be covered are factors governing the materials physical properties and structure-property relationship in electronic device applications. The prospect of using low cost printing techniques such as inkjet, screen, and gravure printing in the fabrication of roll-to-roll organic based devices will be discussed. Encapsulation, lifetime and reliability issues will also be presented. Prerequisites: Organic Chemistry 1 & 2 are encouraged. 3 hours lecture; 3 semester hours.
View Course Learning Outcomes
- Ability to apply the knowledge on Organic Semiconductors and Structure-Property relationships to future research and engineering problems
CHGN540. PROFESSIONAL SKILLS FOR CHEMICAL SCIENTISTS. 1.0 Semester Hr.
The goal of this course is to provide students a set of skills that are complementary to their core education. The contents of this course cover a broad range of topics that will provide the participants a perspective on careers in science and the skill sets necessary to be successful in each. These skills are in line with the latest recommendations of the American Chemical Society (ACS) and CSM educational goals. In particular, the 2013 ACS Presidential Commission Report on Graduate Education in the Chemical Sciences presents a platform for educational reform that includes a focus on multi-level (from general public to specialists) and multi-platform communication (formal and informal, written, oral), an understanding of the global chemical enterprise and the career possibilities within each, an understanding of networking and collaboration, etc. 1 hour lecture; 1 semester hour.
CHGN545. CHEMICAL BIOLOGY. 3.0 Semester Hrs.
The analysis of biological systems from the perspective of organic/inorganic and physical chemistry, including chemical reactions for the synthetic preparation of biomolecules and the chemistry behind different biotechnological developments and tools. A strong emphasis on the mechanistic basis of biochemical transformations is included. Strategies for directing pharmaceuticals or diagnostics to different subcellular locales will be presented. A survey of key advancements in the field of chemical biology will be drawn from the primary literature. Prerequisite: CHGN 222, CHGN 428.
CHGN555. POLYMER AND COMPLEX FLUIDS COLLOQUIUM. 1.0 Semester Hr.
Equivalent with CBEN555,MLGN555,
The Polymer and Complex Fluids Group at the Colorado School of Mines combines expertise in the areas of flow and field based transport, intelligent design and synthesis as well as nanomaterials and nanotechnology. A wide range of research tools employed by the group includes characterization using rheology, scattering, microscopy, microfluidics and separations, synthesis of novel macromolecules as well as theory and simulation involving molecular dynamics and Monte Carlo approaches. The course will provide a mechanism for collaboration between faculty and students in this research area by providing presentations on topics including the expertise of the group and unpublished, ongoing campus research. Prerequisites: none. 1 hour lecture; 1 semester hour. Repeatable for credit to a maximum of 3 hours.
CHGN560. GRADUATE SEMINAR. 1.0 Semester Hr.
Required for all candidates for the M.S. and Ph.D. degrees in Chemistry. Full-time graduate students resident on campus must register for the course during each semester of their first four years of residency. Attendance at most departmental seminars is required, and all graduate students are required to present a departmental seminar. Prerequisite: Enrollment in Chemistry M.S. or Ph.D. degree program.
CHGN580. STRUCTURE OF MATERIALS. 3.0 Semester Hrs.
(II) Application of X-ray diffraction techniques for crystal and molecular structure determination of minerals, inorganic and organometallic compounds. Topics include the heavy atom method, data collection by moving film techniques and by diffractometers, Fourier methods, interpretation of Patterson maps, refinement methods, direct methods. Prerequisite: none. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN581. ELECTROCHEMISTRY. 3.0 Semester Hrs.
(I) Introduction to theory and practice of electrochemistry. Electrode potentials, reversible and irreversible cells, activity concept. Interionic attraction theory, proton transfer theory of acids and bases, mechanisms and fates of electrode reactions. Prerequisite: none. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN583. PRINCIPLES AND APPLICATIONS OF SURFACE ANALYSIS TECHNIQUES. 3.0 Semester Hrs.
(II) Instrumental techniques for the characterization of surfaces of solid materials; Applications of such techniques to polymers, corrosion, metallurgy, adhesion science, microelectronics. Methods of analysis discussed: x-ray photoelectron spectroscopy (XPS), auger electron spectroscopy (AES), ion scattering spectroscopy (ISS), secondary ion mass spectrometry (SIMS), Rutherford backscattering (RBS), scanning and transmission electron microscopy (SEM, TEM), energy and wavelength dispersive x-ray analysis; principles of these methods, quantification, instrumentation, sample preparation. 3 hours lecture; 3 semester hours. Prerequisite: B.S. in Metallurgy, Chemistry, Chemical Engineering, Physics, or consent of instructor.
CHGN584. FUNDAMENTALS OF CATALYSIS. 3.0 Semester Hrs.
(II) The basic principles involved in the preparation, characterization, testing and theory of heterogeneous and homo geneous catalysts are discussed. Topics include chemisorption, adsorption isotherms, diffusion, surface kinetics, promoters, poisons, catalyst theory and design, acid base catalysis and soluble transition metal complexes. Examples of important industrial applications are given. Prerequisite: CHGN222. 3 hours lecture; 3 semester hours.
CHGN585. CHEMICAL KINETICS. 3.0 Semester Hrs.
(II) Study of kinetic phenomena in chemical systems. Attention devoted to various theoretical approaches. Prerequisite: none. 3 hours lecture; 3 semester hours. Offered alternate years.
CHGN598. SPECIAL TOPICS IN CHEMISTRY. 0-6 Semester Hr.
(I, II, S) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once, but no more than twice for the same course content. Prerequisite: none. Variable credit: 0 to 6 credit hours. Repeatable for credit under different titles.
CHGN599. INDEPENDENT STUDY. 0.5-6 Semester Hr.
(I, II, S) Individual research or special problem projects supervised by a faculty member, also, when a student and instructor agree on a subject matter, content, and credit hours. Prerequisite: “Independent Study” form must be completed and submitted to the Registrar. Variable credit: 0.5 to 6 credit hours. Repeatable for credit under different topics/experience and maximums vary by department. Contact the Department for credit limits toward the degree.
CHGN625. MOLECULAR SIMULATION. 3.0 Semester Hrs.
Principles and practice of modern computer simulation techniques used to understand solids, liquids, and gases. Review of the statistical foundation of thermodynamics followed by indepth discussion of Monte Carlo and Molecular Dynamics techniques. Discussion of intermolecular potentials, extended ensembles, and mathematical algorithms used in molecular simulations. 3 hours lecture; 3 semester hours. Prerequisite: CBEN 509 or equivalent, and recommend CBEN 610 or equivalent.
CHGN698. SPECIAL TOPICS IN CHEMISTRY. 0-6 Semester Hr.
(I, II, S) Pilot course or special topics course. Topics chosen from special interests of instructor(s) and student(s). Usually the course is offered only once, but no more than twice for the same course content. Prerequisite: none. Variable credit: 0 to 6 credit hours. Repeatable for credit under different titles.
CHGN699. INDEPENDENT STUDY. 0.5-6 Semester Hr.
(I, II, S) Individual research, special problem projects, or internship supervised by a Chemistry faculty member, with student and instructor agreeing on a subject matter, content, deliverables, and credit hours. Variable credit: 0.5 to 6 credit hours. Repeatable for credit under different topics/experience and maximums vary by department. Contact the Department for credit limits toward the degree. Prerequisites: “Independent Study” form must be completed and submitted to the Registrar.
CHGN699. INDEPENDENT STUDY. 0.5-6 Semester Hr.
(I, II, S) Individual research, special problem projects, or internship supervised by a Chemistry faculty member, with student and instructor agreeing on a subject matter, content, deliverables, and credit hours. Variable credit: 0.5 to 6 credit hours. Repeatable for credit under different topics/experience and maximums vary by department. Contact the Department for credit limits toward the degree.
CHGN707. GRADUATE THESIS / DISSERTATION RESEARCH CREDIT. 1-15 Semester Hr.
(I, II, S) Research credit hours required for completion of a Masters-level thesis or Doctoral dissertation. Research must be carried out under the direct supervision of the student's faculty advisor. Variable class and semester hours. Repeatable for credit.